Recurring fever in adults
Following cimetidine therapy, her periodic symptoms diminished. PFAPA syndrome should be considered in patients presenting with periodic fever and upper respiratory symptoms regardless of their age or ethnicity. There was no remarkable family history except for her mother's neuromyelitis optica. Her menstrual period was regular. She had never traveled abroad. On admission, her body temperature was
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We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission. The normal human body temperature is about A fever is when the temperature rises above a normal range. A low grade fever occurs when the body temperature becomes very slightly elevated, usually between about The fever is persistent when the body temperature stays in this range for more than 2 weeks. A fever is commonly a result of the body trying to fight off an infection or another illness.
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Periodic fever syndromes PFS are a group of rare autoinflammatory diseases characterized by inappropriate, uncontrolled, and often spontaneous signs and symptoms of inflammation. The recurrent febrile episodes occur in the absence of infection or evidence of active autoimmunity. Fevers in PFS are due to abnormalities in activation of the innate immune system.
A number of autoinflammatory syndromes that result from genetic mutations have been described recently. The vast majority occur in children. However, three periodic fever syndromes are important for rheumatologists who treat adults to know about. The goal of this review is to provide a concise description of each condition, and to help the clinician understand when to suspect one and how to diagnose it.